After well over a decade of dominance from the New England Patriots, the Buffalo Bills have won the AFC East the last four years. However, after losing an epic AFC Championship Game against the Chiefs in 2020-21, Buffalo has been bounced in the NFL Divisional Round the last three seasons. The Bills will open their season against the Arizona Cardinals on Sunday and Josh Allen has designs of getting his franchise back into the title conversation. Buffalo is favored by six in the Week 1 NFL odds, one of the largest NFL spreads of the week. So which Week 1 NFL lines are off and how can you dial in your Week 1 NFL score predictions? Before you make any Week 1 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.
In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine’s AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.
For Week 1, the AI PickBot has evaluated the NFL odds and provided NFL predictions for all 16 games. You can only see the AI predictions for the Week 1 NFL schedule here.
Top Week 1 NFL AI picks
After analyzing every game in Week 1, the AI PickBot says the Broncos cover as six-point underdogs against the Seahawks in a game that has earned an A-rated pick. The Broncos will break in a rookie quarterback this season, with No. 12 overall pick Bo Nix winning the starting job over Jarrett Stidham and Zach Wilson this offseason. That seems to be fueling a pullback from oddsmakers, with Denver’s over/under for wins set at six despite Sean Payton leading the team to eight wins in 2023.
However, Payton has raved about Nix’s accuracy all summer and this will be the first time since 2021 that the Broncos have had coaching staff continuity from one season to the next. Meanwhile, Seattle is breaking in a brand-new coaching staff after mutually parting ways with Pete Carroll after 14 years. Ultimately, the Seahawks may still have a slightly better roster, but the AI PickBot is expecting a competitive game with an average final score of Seahawks 21.86, Broncos 20.34. See its other Week 1 football predictions and football picks at SportsLine.
How to make Week 1 NFL picks
In addition, the AI PickBot has generated eight more A-rated picks for Week 1. You need to see the AI PickBot’s analysis before making any Week 1 NFL bets. You can only see it at SportsLine.
Who wins and covers each Week 1 NFL game, and which A-rated picks should you be targeting? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.
